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American Society of Microbiology ABMM Sample Questions:
1. A laboratory worker sustains a needlestick injury while handling a blood sample known to be positive for Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg). The worker has completed the HBV vaccination series and has a documented anti-HBs titer >10 mIU/mL one month ago. What is the recommended post-exposure prophylaxis?
A) Both HBIG and HBV vaccine booster dose
B) Hepatitis B vaccine booster dose only
C) No treatment required
D) Hepatitis B immune globulin (HBIG) only
2. A clinical microbiology laboratory is monitoring the emergence of resistance to colistin in Gram-negative bacteria. Resistance to colistin is often mediated by modifications of the bacterial lipopolysaccharide (LPS).
The genetic basis for acquired colistin resistance most commonly involves:
A) Acquisition of genes encoding efflux pumps that specifically target colistin.
B) Production of enzymes that directly inactivate the colistin molecule.
C) Mutations in genes encoding enzymes that modify the lipid A component of LPS.
D) Alterations in the outer membrane porin proteins, reducing colistin uptake.
3. During an investigation of a foodborne outbreak linked to a church supper, 80 people ate the suspected chicken dish, and 32 subsequently developed gastroenteritis. Among 50 people who did not eat the chicken dish, 5 developed similar symptoms. What is the attack rate among those who ate the chicken dish?
A) 40%
B) 5%
C) 64%
D) 10%
4. A patient with a history of inflammatory bowel disease is diagnosed with primary sclerosing cholangitis and undergoes liver transplantation. Post-transplant, they develop a bloodstream infection with a Gram-negative bacterium that is identified as Fusobacterium nucleatum. This organism's role in the pathogenesis of colorectal cancer is primarily attributed to its ability to:
A) Form biofilms that physically obstruct the bile ducts.
B) Modulate the host immune response and promote a pro-inflammatory microenvironment.
C) Directly induce mutations in colonic epithelial cells.
D) Produce potent exotoxins that damage the intestinal epithelium.
5. A patient with a history of recurrent urinary tract infections caused by Escherichia coli develops a new infection. The urine isolate is resistant to trimethoprim-sulfamethoxazole. The MOST common mechanism of resistance to this antibiotic combination in E. coli involves:
A) Mutations in the genes encoding dihydrofolate reductase and dihydropteroate synthase.
B) Expression of efflux pumps that specifically target trimethoprim and sulfamethoxazole.
C) Increased production of para-aminobenzoic acid (PABA).
D) Enzymatic inactivation of trimethoprim and sulfamethoxazole.
Solutions:
| Question # 1 Answer: C | Question # 2 Answer: C | Question # 3 Answer: A | Question # 4 Answer: B | Question # 5 Answer: A |







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